The value of somatostatin receptor imaging with In-111 Octreotide and/or Ga-68 DOTATATE in localizing Ectopic ACTH producing tumors.
Identifieur interne : 000323 ( Main/Exploration ); précédent : 000322; suivant : 000324The value of somatostatin receptor imaging with In-111 Octreotide and/or Ga-68 DOTATATE in localizing Ectopic ACTH producing tumors.
Auteurs : RBID : pubmed:24003397Abstract
Objective: We aimed to evaluate the value of somatostatin receptor imaging (SRI) with In-111 octreotide and Ga-68 DOTATATE in localizing ectopic ACTH producing tumors. Methods: Nineteen patients who had In-111 octreotide somatostatin receptor scintigraphy (SRS) and/or Ga-68 DOTATATE PET-CT to localize ectopic ACTH producing tumors between the years 2000 and 2012 were included retrospectively in our study. The results of SRI were compared with clinical onset, radiological findings and surgical data of the patients. Results: Sixteen In-111 octreotide SRS and five Ga-68 DOTATATE PET-CT were performed in 19 patients. In eight out of 19 patients, ectopic ACTH secretion site could be detected. In five patients, SRS showed pathologic uptake. In four of these patients, surgery revealed pulmonary carcinoid tumors and in one patient pancreatic neuroendocrine tumor. In one patient, Ga-68 DOTATATE PET-CT revealed pathologic uptake in lung nodule which came out to be pulmonary carcinoid tumor. In another patient who had resection of metastases of atypical carcinoid tumor prior to scans, new metastatic foci were detected both with SRS and Ga-68 DOTATATE PET-CT imaging. In one patient, although SRS was negative, CT which was performed three years later showed a lung nodule diagnosed as pulmonary carcinoid tumor. In 11 patients, ectopic ACTH secretion site could not be detected. In 10 of those patients, scintigraphic and radiological imaging did not show any lesions and in one patient, Ga-68 DOTATATE PET-CT was false positive. Conclusion: SRI has a complementary role with radiological imaging in localizing ectopic ACTH secretion sites. PET-CT imaging with Ga-68 peptide conjugates is a promising new modality for this indication. Conflict of interest:None declared.
DOI: 10.4274/Mirt.69775
PubMed: 24003397
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The value of somatostatin receptor imaging with In-111 Octreotide and/or Ga-68 DOTATATE in localizing Ectopic ACTH producing tumors.</title><author><name sortKey="Ozkan, Zeynep G Zde" uniqKey="Ozkan Z">Zeynep Gözde Özkan</name><affiliation wicri:level="1"><nlm:affiliation>İstanbul University İstanbul Medical Faculty, Nuclear Medicine Department, İstanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>İstanbul University İstanbul Medical Faculty, Nuclear Medicine Department, İstanbul</wicri:regionArea></affiliation></author><author><name sortKey="Kuyumcu, Serkan" uniqKey="Kuyumcu S">Serkan Kuyumcu</name></author><author><name sortKey="Balk Se, Deniz" uniqKey="Balk Se D">Deniz Balköse</name></author><author><name sortKey="Ozkan, Berker" uniqKey="Ozkan B">Berker Ozkan</name></author><author><name sortKey="Aksakal, Nihat" uniqKey="Aksakal N">Nihat Aksakal</name></author><author><name sortKey="Y Lmaz, Ebru" uniqKey="Y Lmaz E">Ebru Yılmaz</name></author><author><name sortKey="Sanl, Yasemin" uniqKey="Sanl Y">Yasemin Sanlı</name></author><author><name sortKey="T Rkmen, C Neyt" uniqKey="T Rkmen C">Cüneyt Türkmen</name></author><author><name sortKey="Aral, Ferihan" uniqKey="Aral F">Ferihan Aral</name></author><author><name sortKey="Adalet, I Ik" uniqKey="Adalet I">Işik Adalet</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.4274/Mirt.69775</idno><idno type="RBID">pubmed:24003397</idno><idno type="pmid">24003397</idno><idno type="wicri:Area/Main/Corpus">000422</idno><idno type="wicri:Area/Main/Curation">000422</idno><idno type="wicri:Area/Main/Exploration">000323</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: We aimed to evaluate the value of somatostatin receptor imaging (SRI) with In-111 octreotide and Ga-68 DOTATATE in localizing ectopic ACTH producing tumors. Methods: Nineteen patients who had In-111 octreotide somatostatin receptor scintigraphy (SRS) and/or Ga-68 DOTATATE PET-CT to localize ectopic ACTH producing tumors between the years 2000 and 2012 were included retrospectively in our study. The results of SRI were compared with clinical onset, radiological findings and surgical data of the patients. Results: Sixteen In-111 octreotide SRS and five Ga-68 DOTATATE PET-CT were performed in 19 patients. In eight out of 19 patients, ectopic ACTH secretion site could be detected. In five patients, SRS showed pathologic uptake. In four of these patients, surgery revealed pulmonary carcinoid tumors and in one patient pancreatic neuroendocrine tumor. In one patient, Ga-68 DOTATATE PET-CT revealed pathologic uptake in lung nodule which came out to be pulmonary carcinoid tumor. In another patient who had resection of metastases of atypical carcinoid tumor prior to scans, new metastatic foci were detected both with SRS and Ga-68 DOTATATE PET-CT imaging. In one patient, although SRS was negative, CT which was performed three years later showed a lung nodule diagnosed as pulmonary carcinoid tumor. In 11 patients, ectopic ACTH secretion site could not be detected. In 10 of those patients, scintigraphic and radiological imaging did not show any lesions and in one patient, Ga-68 DOTATATE PET-CT was false positive. Conclusion: SRI has a complementary role with radiological imaging in localizing ectopic ACTH secretion sites. PET-CT imaging with Ga-68 peptide conjugates is a promising new modality for this indication. Conflict of interest:None declared.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="PubMed-not-MEDLINE"><PMID Version="1">24003397</PMID><DateCreated><Year>2013</Year><Month>09</Month><Day>04</Day></DateCreated><DateCompleted><Year>2013</Year><Month>09</Month><Day>04</Day></DateCompleted><DateRevised><Year>2014</Year><Month>05</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2146-1414</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>2</Issue><PubDate><Year>2013</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Molecular imaging and radionuclide therapy</Title><ISOAbbreviation>Mol Imaging Radionucl Ther</ISOAbbreviation></Journal><ArticleTitle>The value of somatostatin receptor imaging with In-111 Octreotide and/or Ga-68 DOTATATE in localizing Ectopic ACTH producing tumors.</ArticleTitle><Pagination><MedlinePgn>49-55</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4274/Mirt.69775</ELocationID><Abstract><AbstractText>Objective: We aimed to evaluate the value of somatostatin receptor imaging (SRI) with In-111 octreotide and Ga-68 DOTATATE in localizing ectopic ACTH producing tumors. Methods: Nineteen patients who had In-111 octreotide somatostatin receptor scintigraphy (SRS) and/or Ga-68 DOTATATE PET-CT to localize ectopic ACTH producing tumors between the years 2000 and 2012 were included retrospectively in our study. The results of SRI were compared with clinical onset, radiological findings and surgical data of the patients. Results: Sixteen In-111 octreotide SRS and five Ga-68 DOTATATE PET-CT were performed in 19 patients. In eight out of 19 patients, ectopic ACTH secretion site could be detected. In five patients, SRS showed pathologic uptake. In four of these patients, surgery revealed pulmonary carcinoid tumors and in one patient pancreatic neuroendocrine tumor. In one patient, Ga-68 DOTATATE PET-CT revealed pathologic uptake in lung nodule which came out to be pulmonary carcinoid tumor. In another patient who had resection of metastases of atypical carcinoid tumor prior to scans, new metastatic foci were detected both with SRS and Ga-68 DOTATATE PET-CT imaging. In one patient, although SRS was negative, CT which was performed three years later showed a lung nodule diagnosed as pulmonary carcinoid tumor. In 11 patients, ectopic ACTH secretion site could not be detected. In 10 of those patients, scintigraphic and radiological imaging did not show any lesions and in one patient, Ga-68 DOTATATE PET-CT was false positive. Conclusion: SRI has a complementary role with radiological imaging in localizing ectopic ACTH secretion sites. PET-CT imaging with Ga-68 peptide conjugates is a promising new modality for this indication. Conflict of interest:None declared.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Özkan</LastName><ForeName>Zeynep Gözde</ForeName><Initials>ZG</Initials><Affiliation>İstanbul University İstanbul Medical Faculty, Nuclear Medicine Department, İstanbul, Turkey.</Affiliation></Author><Author ValidYN="Y"><LastName>Kuyumcu</LastName><ForeName>Serkan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Balköse</LastName><ForeName>Deniz</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Ozkan</LastName><ForeName>Berker</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Aksakal</LastName><ForeName>Nihat</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Yılmaz</LastName><ForeName>Ebru</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Sanlı</LastName><ForeName>Yasemin</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Türkmen</LastName><ForeName>Cüneyt</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Aral</LastName><ForeName>Ferihan</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Adalet</LastName><ForeName>Işik</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>08</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Turkey</Country><MedlineTA>Mol Imaging Radionucl Ther</MedlineTA><NlmUniqueID>101584839</NlmUniqueID></MedlineJournalInfo><OtherID Source="NLM">PMC3759309</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cushing syndrome</Keyword><Keyword MajorTopicYN="N">ectopic ACTH Syndrome</Keyword><Keyword MajorTopicYN="N">gallium radioisotopes</Keyword><Keyword MajorTopicYN="N">indium-111-octreotide</Keyword><Keyword MajorTopicYN="N">positron-emission tomography/computed tomography</Keyword><Keyword MajorTopicYN="N">scintigraphy</Keyword><Keyword MajorTopicYN="N">somatostatin receptor</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>4</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>6</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="epublish"><Year>2013</Year><Month>8</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>9</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>9</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>9</Month><Day>5</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.4274/Mirt.69775</ArticleId><ArticleId IdType="pubmed">24003397</ArticleId><ArticleId IdType="pmc">PMC3759309</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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